Haplotype tagging for the identification of common disease genes.

Journal article

Genome-wide linkage disequilibrium (LD) mapping of common disease genes could be more powerful than linkage analysis if the appropriate density of polymorphic markers were known and if the genotyping effort and cost of producing such an LD map could be reduced. Although different metrics that measure the extent of LD have been evaluated, even the most recent studies have not placed significant emphasis on the most informative and cost-effective method of LD mapping-that based on haplotypes. W...

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Authors: Johnson, G; Esposito, L; Barratt, B; Smith, A; Heward, J

• Journal: Nature genetics
• Volume: 29
• Issue: 2
• Pages: 233-237
• Publication date: 2001-10-01
• DOI: 10.1038/ng1001-233
• EISSN: 1546-1718
• ISSN: 1061-4036
• Language: English
• Keywords: Linkage Disequilibrium; Humans; Base Sequence; Polymorphism, Single Nucleotide; Genetic Predisposition to Disease; Haplotypes; Sequence Homology, Nucleic Acid; DNA