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Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice.

Abstract:

The NMDA receptor-mediated Ca2+ signaling during simultaneous pre- and postsynaptic activity is critically involved in synaptic plasticity and thus has a key role in the nervous system. In GRIN2-variant patients alterations of this coincidence detection provoked complex clinical phenotypes, ranging from reduced muscle strength to epileptic seizures and intellectual disability. By using our gene-targeted mouse line (Grin2aN615S), we show that voltage-independent glutamate...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s42003-020-01538-4

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Role:
Author
ORCID:
0000-0002-2880-716X
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Role:
Author
ORCID:
0000-0002-4932-4095
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Role:
Author
ORCID:
0000-0002-2446-6994
Publisher:
Springer Nature
Journal:
Communications Biology More from this journal
Volume:
4
Issue:
1
Article number:
59
Publication date:
2021-01-08
Acceptance date:
2020-11-20
DOI:
EISSN:
2399-3642
Pmid:
33420383
Language:
English
Keywords:
Pubs id:
1156546
Local pid:
pubs:1156546
Deposit date:
2021-02-19

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