Human immunodeficiency viruses: neutralization and receptors.

Journal article

The envelope glycoproteins of HIV, gp120 and gp41, contain epitopes recognized by neutralizing antibodies. Studies of human sera from infected individuals indicate that group-specific neutralization antigens common to most isolates of HIV-1 exist, and that some HIV-2 antisera cross-neutralize HIV-1. Neutralization epitopes for HIV-1 have been identified and mapped, including a group-specific antigen on gp41, and a type-specific antigen on gp120. Neutralization "escape" mutants have been selec...

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Authors: Weiss, R; Clapham, P; McClure, M; McKeating, J; McKnight, A

• Publication status: Published
• Journal: Journal of acquired immune deficiency syndromes
• Volume: 1
• Issue: 6
• Pages: 536-541
• Publication date: 1988-01-01
• ISSN: 0894-9255
• Language: English
• Keywords: Humans; Animals; HIV Antigens; Epitopes; Antigens, Differentiation, T-Lymphocyte; Receptors, Immunologic; Neutralization Tests; T-Lymphocytes; Antigenic Variation; HIV; Receptors, Virus