Journal article
Neurophysiological correlates of trait impulsivity in Parkinson's disease
- Abstract:
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Background
Impulsivity is common in people with Parkinson's disease (PD), with many developing impulsive compulsive behavior disorders (ICB). Its pathophysiological basis remains unclear.
Objectives
We aimed to investigate local field potential (LFP) markers of trait impulsivity in PD and their relationship to ICB.
Methods
We recorded subthalamic nucleus (STN) LFPs in 23 PD patients undergoing deep brain stimulation implantation. Presence and severity of ICB were assessed by clinical interview and the Questionnaire for Impulsive-Compulsive Disorders in PD-Rating Scale (QUIP-RS), whereas trait impulsivity was estimated with the Barratt Impulsivity Scale (BIS-11). Recordings were obtained during the off dopaminergic states and the power spectrum of the subthalamic activity was analyzed using Fourier transform-based techniques. Assessment of each electrode contact localization was done to determine the topography of the oscillatory activity recorded.
Results
Patients with (n = 6) and without (n = 17) ICB had similar LFP spectra. A multiple regression model including QUIP-RS, BIS-11, and Unified PD Rating Scale-III scores as regressors showed a significant positive correlation between 8–13 Hz power and BIS-11 score. The correlation was mainly driven by the motor factor of the BIS-11, and was irrespective of the presence or absence of active ICB. Electrode contact pairs with the highest α power, which also correlated most strongly with BIS-11, tended to be more ventral than contact pairs with the highest beta power, which localize to the dorsolateral motor STN.
Conclusions
Our data suggest a link between α power and trait impulsivity in PD, irrespective of the presence and severity of ICB. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 691.4KB, Terms of use)
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- Publisher copy:
- 10.1002/mds.28625
Authors
- Publisher:
- Wiley
- Journal:
- Movement Disorders More from this journal
- Volume:
- 36
- Issue:
- 9
- Pages:
- 2126-2135
- Publication date:
- 2021-05-13
- Acceptance date:
- 2021-04-05
- DOI:
- EISSN:
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1531-8257
- ISSN:
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0885-3185
- Pmid:
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33982824
- Language:
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English
- Keywords:
- Pubs id:
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1176710
- Local pid:
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pubs:1176710
- Deposit date:
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2021-06-24
- ARK identifier:
Terms of use
- Copyright holder:
- Ricciardi et al.
- Copyright date:
- 2021
- Rights statement:
- ©2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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