Journal article
Prevalence of clinically relevant UGT1A alleles and haplotypes in African populations.
- Abstract:
-
Variation of a short (TA)(n) repeat sequence (rs8175347) covering the TATA box of UGT1A1 (UDP-glucuronosyltransferase1A1) is associated with hyperbilirubinaemia (Gilbert's syndrome) and adverse drug reactions, and is used for dosage advice for irinotecan. Several reports indicate that the low-activity (risk) alleles ((TA)(7) and (TA)(8) )) are very frequent in Africans but the patterns of association with other variants in the UGT1A gene complex that may modulate these responses are not well ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Melford Charitable Trust
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Bibliographic Details
- Publisher:
- John Wiley and Sons Publisher's website
- Journal:
- Annals of human genetics Journal website
- Volume:
- 75
- Issue:
- 2
- Pages:
- 236-246
- Publication date:
- 2011-03-01
- DOI:
- EISSN:
-
1469-1809
- ISSN:
-
0003-4800
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:266104
- UUID:
-
uuid:a6c81d66-fbfb-4619-92bb-16a02f02f7c9
- Local pid:
- pubs:266104
- Source identifiers:
-
266104
- Deposit date:
- 2013-11-17
Terms of use
- Copyright holder:
- Horsfall et al
- Copyright date:
- 2011
- Notes:
- Copyright 2011 The Authors. Annals of Human Genetics Copyright 2011 Blackwell Publishing Ltd/University College London. This is the peer reviewed version of the following article: Horsfall, L. J., Zeitlyn, D., Tarekegn, A., Bekele, E., Thomas, M. G., Bradman, N. and Swallow, D. M. (2011), Prevalence of Clinically Relevant UGT1A Alleles and Haplotypes in African Populations. Annals of Human Genetics, 75: 236–246. doi: 10.1111/j.1469-1809.2010.00638.x. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving http://olabout.wiley.com/WileyCDA/Section/id-817011.html
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