Journal article
Asymmetric synthesis of pyrrolizidines, indolizidines and quinolizidines via a double reductive cyclisation protocol
- Abstract:
-
This account describes an overview of the asymmetric syntheses of pyrrolizidines, indolizidines and quinolizidines via a common double reductive cyclisation protocol. The highly diastereoselective conjugate addition of an enantiopure lithium amide to an α,β-unsaturated ester incorporating a terminal C=C bond installed the nitrogen bearing stereogenic centre and was followed by alkenylation of the corresponding enolate to introduce the second olefinic functionality. Alternatively, conjugate ad...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Thieme Publishing Publisher's website
- Journal:
- Synlett Journal website
- Volume:
- 28
- Issue:
- 20
- Pages:
- 2697-2706
- Publication date:
- 2017-08-08
- Acceptance date:
- 2017-07-04
- DOI:
- EISSN:
-
1437-2096
- ISSN:
-
0936-5214
Item Description
- Keywords:
- Pubs id:
-
pubs:703084
- UUID:
-
uuid:a6c406f3-762b-467f-9883-0d920a6ee3e6
- Local pid:
- pubs:703084
- Source identifiers:
-
703084
- Deposit date:
- 2017-07-06
Terms of use
- Copyright holder:
- Georg Thieme Verlag
- Copyright date:
- 2017
- Notes:
- © Georg Thieme Verlag Stuttgart · New York. This is the accepted manuscript version of the article. The final version is available online from Georg Thieme at: http://dx.doi.org/10.1055/s-0036-1590975
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