Blood eosinophils to guide inhaled maintenance therapy in a primary care COPD population

Ashdown, HF; Smith, M; McFadden, E; Pavord, ID; Butler, CC; Bafadhel, M

Journal article

Blood eosinophils to guide inhaled maintenance therapy in a primary care COPD population

Abstract:: Blood eosinophils are a potentially useful biomarker for guiding inhaled corticosteroid (ICS) treatment decisions in COPD. We investigated whether existing blood eosinophil counts predict benefit from initiation of ICS compared to bronchodilator therapy.

We used routinely collected data from UK primary care in the Clinical Practice Research Datalink. Participants were aged ≥40 years with COPD, were ICS-naïve and starting a new inhaled maintenance medication (intervention group: ICS; comparator group: long-acting bronchodilator, non-ICS). Primary outcome was time to first exacerbation, compared between ICS and non-ICS groups, stratified by blood eosinophils (“high” ≥150 cells·µL⁻¹ and “low” <150 cells·µL⁻¹).

Out of 9475 eligible patients, 53.9% initiated ICS and 46.1% non-ICS treatment with no difference in eosinophils between treatment groups (p=0.71). Exacerbation risk was higher in patients prescribed ICS than those prescribed non-ICS treatment, but with a lower risk in those with high eosinophils (hazard ratio (HR) 1.04, 95% CI 0.98–1.10) than low eosinophils (HR 1.19, 95% CI 1.09–1.31) (p-value for interaction 0.01). Risk of pneumonia hospitalisation with ICS was greatest in those with low eosinophils (HR 1.26, 95% CI 1.05–1.50; p-value for interaction 0.04). Results were similar whether the most recent blood eosinophil count or the mean of blood eosinophil counts was used.

In a primary care population, the most recent blood eosinophil count could be used to guide initiation of ICS in COPD patients. We suggest that ICS should be considered in those with higher eosinophils and avoided in those with lower eosinophils (<150 cells·µL⁻¹).

Publication status:: Published

Peer review status:: Peer reviewed

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Share
Cite

Cite this record

APA Style

Ashdown, H. F., Smith, M., McFadden, E., Pavord, I. D., Butler, C. C., & Bafadhel, M. (2021). Blood eosinophils to guide inhaled maintenance therapy in a primary care COPD population. ERJ Open Research, 8(1).

MLA Style

Ashdown, HF, et al. “Blood Eosinophils to Guide Inhaled Maintenance Therapy in a Primary Care COPD Population.” ERJ Open Research, vol. 8, no. 1, 2021.

Chicago Style

Ashdown, HF, M Smith, E McFadden, ID Pavord, CC Butler, and M Bafadhel. 2021. “Blood Eosinophils to Guide Inhaled Maintenance Therapy in a Primary Care COPD Population.” ERJ Open Research 8 (1).
Print