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Journal article

A core matrisome gene signature predicts cancer outcome

Abstract:

Background: Accumulating evidence implicates the tumour stroma as an important determinant of cancer progression but the protein constituents relevant for this effect are unknown. Here we utilised a bioinformatics approach to identify an extracellular matrix (ECM) gene signature overexpressed in multiple cancer types and strongly predictive of adverse outcome.

Methods: Gene expression levels in cancers were determined using Oncomine. Geneset enrichment analysis was pe...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/bjc.2017.458

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology; CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Role:
Author
Publisher:
Cancer Research UK Publisher's website
Journal:
British Journal of Cancer Journal website
Volume:
118
Pages:
435–440
Publication date:
2018-01-23
Acceptance date:
2017-11-22
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
Pmid:
29360819
Source identifiers:
821840
Language:
English
Keywords:
Pubs id:
pubs:821840
UUID:
uuid:a69d58d7-fd18-47f4-b592-5d4d82af1e04
Local pid:
pubs:821840
Deposit date:
2018-02-07

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