A core matrisome gene signature predicts cancer outcome
Background: Accumulating evidence implicates the tumour stroma as an important determinant of cancer progression but the protein constituents relevant for this effect are unknown. Here we utilised a bioinformatics approach to identify an extracellular matrix (ECM) gene signature overexpressed in multiple cancer types and strongly predictive of adverse outcome.
Methods: Gene expression levels in cancers were determined using Oncomine. Geneset enrichment analysis was pe...Expand abstract
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- Peer reviewed
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- Cancer Research UK
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- Copyright © 2018 Cancer Research UK. This article has been made available under a Creative Commons AttributionNonCommercial-Share Alike 4.0 Unported License.
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