Efficacy and safety of intramuscular administration of tixagevimab-cilgavimab for early outpatient treatment of COVID-19 (TACKLE): a phase 3, randomised, double-blind, placebo-controlled trial

Montgomery, H; Hobbs, FDR; Padilla, F; Arbetter, D; Templeton, A; Seegobin, S; Kim, K; Campos, JAS; Arends, RH; Brodek, BH; Brooks, D; Garbes, P; Jimenez, J; Koh, GCKW; Padilla, KW; Streicher, K; Viani, RM; Alagappan, V; Pangalos, MN; Esser, MT; TACKLE Study Group

Journal article

Efficacy and safety of intramuscular administration of tixagevimab-cilgavimab for early outpatient treatment of COVID-19 (TACKLE): a phase 3, randomised, double-blind, placebo-controlled trial

Abstract:: Background: Early intramuscular administration of SARS-CoV-2-neutralising monoclonal antibody combination, tixagevimab–cilgavimab, to non-hospitalised adults with mild to moderate COVID-19 has potential to prevent disease progression. We aimed to evaluate the safety and efficacy of tixagevimab–cilgavimab in preventing progression to severe COVID-19 or death.

Methods: TACKLE is an ongoing, phase 3, randomised, double-blind, placebo-controlled study ...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Montgomery, H., Hobbs, F. D. R., Padilla, F., Arbetter, D., Templeton, A., Seegobin, S., Kim, K., Campos, J. A. S., Arends, R. H., Brodek, B. H., Brooks, D., Garbes, P., Jimenez, J., Koh, G. C. K. W., Padilla, K. W., Streicher, K., Viani, R. M., Alagappan, V., Pangalos, M. N., … Group, T. A. C. K. L. E. S. (2022). Efficacy and safety of intramuscular administration of tixagevimab-cilgavimab for early outpatient treatment of COVID-19 (TACKLE): a phase 3, randomised, double-blind, placebo-controlled trial. Lancet Respiratory Medicine, 10(10), 985–996.

MLA Style

Montgomery, H., et al. “Efficacy and Safety of Intramuscular Administration of Tixagevimab-Cilgavimab for Early Outpatient Treatment of COVID-19 (TACKLE): a Phase 3, Randomised, Double-Blind, Placebo-Controlled Trial.” Lancet Respiratory Medicine, vol. 10, no. 10, Elsevier, 2022, pp. 985–96.

Chicago Style

Montgomery, H, FDR Hobbs, F Padilla, D Arbetter, A Templeton, S Seegobin, K Kim, et al. 2022. “Efficacy and Safety of Intramuscular Administration of Tixagevimab-Cilgavimab for Early Outpatient Treatment of COVID-19 (TACKLE): a Phase 3, Randomised, Double-Blind, Placebo-Controlled Trial.” Lancet Respiratory Medicine 10 (10): 985–96.
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