Journal article icon

Journal article

Suppression of thromboxane A2 but not of systemic prostacyclin by controlled-release aspirin.

Abstract:

BACKGROUND: The antithrombotic efficacy of aspirin is attributed to its inhibition of the enzyme prostaglandin G/H synthase, which is necessary for the formation of thromboxane A2 in platelets. Thromboxane A2 is a potent vasoconstrictor and platelet agonist. However, the formation of prostacyclin by vascular endothelium also requires prostaglandin G/H synthase, and prostacyclin exerts opposite effects on platelet function and vascular tone. We wanted to see whether controlled-release aspirin ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1056/nejm199110173251605

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
Journal:
New England journal of medicine More from this journal
Volume:
325
Issue:
16
Pages:
1137-1141
Publication date:
1991-10-01
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
Language:
English
Keywords:
Pubs id:
pubs:85301
UUID:
uuid:a68d56ae-abaf-4fa3-b151-039b597312a7
Local pid:
pubs:85301
Source identifiers:
85301
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP