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A conditional model of MLL-AF4 B-cell tumourigenesis using invertor technology.

Abstract:

MLL-AF4 fusion is the most common consequence of chromosomal translocations in infant leukaemia and is associated with a poor prognosis. MLL-AF4 is thought to be required in haematopoietic stem cells to elicit leukaemia and may be involved in tumour phenotype specification as it is only found in B-cell tumours in humans. We have employed the invertor conditional technology to create a model of MLL-AF4, in which a floxed AF4 cDNA was knocked into Mll in the opposite orientation for transcripti...

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Publisher copy:
10.1038/sj.onc.1209636

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Journal:
Oncogene
Volume:
25
Issue:
22
Pages:
3093-3103
Publication date:
2006-05-05
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
URN:
uuid:a6875291-ee96-4341-b631-a564a5178f89
Source identifiers:
324268
Local pid:
pubs:324268

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