A turning point in typhoid control

Journal article

The highest burden of morbidity and mortality associated with Salmonella enterica serovar Typhi and S. enterica serovar Paratyphi A occurs in South and Southeast Asia and in sub-Saharan Africa. In the last 2 decades, significant contributions to our overall understanding of typhoid fever and paratyphoid fever (collectively enteric fever) have been achieved through key population- based disease burden studies. Of particular note, the landmark Diseases of the Most Impoverished (DOMI) project, conducted between 2000 and 2008, documented the high incidence of blood culture–confirmed typhoid and several epidemiological aspects of the disease in 7 Asian countries. Similarly, the Typhoid Surveillance in Africa Program, conducted in 13 countries in sub-Saharan Africa between 2010 and 2014, generated significant data to fill the knowledge gaps on typhoid fever and nontyphoidal Salmonella disease in that geographic region. Despite these large multicountry studies, and other single-country studies published in recent decades, several epidemiological gaps remain. Several current population studies are anticipated to add to the growing body of knowledge on all 3 invasive Salmonella diseases that will make major contributions to their effective control.

Authors: Bentsi-Enchill, A; Pollard, A

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Oxford University Press
• Journal: Journal of Infectious Diseases
• Volume: 218
• Issue: suppl_4
• Pages: S185–S187
• Publication date: 2018-09-05
• Acceptance date: 2018-08-29
• DOI: 10.1093/infdis/jiy417
• EISSN: 1537-6613
• ISSN: 0022-1899
• Pmid: 30189009
• Language: English
• Keywords: Salmonella; typhoid; enteric fever; paratyphoid; surveillance