Journal article
Virological and immunological outcomes in rhesus monkeys after exposure to dengue virus–infected Aedes aegypti mosquitoes
- Abstract:
- This study describes the natural history of dengue virus (DENV) infection in rhesus monkeys exposed to the bites of DENV-infected Aedes aegypti mosquitoes. Dengue virus–infected mosquitoes were generated by either intrathoracic inoculation or by oral feeding on viremic blood meals. Each of the six rhesus monkeys that were fed upon by intrathoracically infected mosquitoes developed NS1 antigenemia and an IgM response; viremia was detected in 4/6 individuals. No virological or immunological evidence of DENV infection was detected in the three monkeys exposed to mosquitoes that had been orally infected with DENV. These results demonstrate the utility of mosquito-borne challenge of rhesus monkeys with DENV.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, 984.3KB, Terms of use)
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- Publisher copy:
- 10.4269/ajtmh.19-0633
Authors
- Publisher:
- American Society of Tropical Medicine and Hygiene
- Journal:
- American Journal of Tropical Medicine and Hygiene More from this journal
- Volume:
- 103
- Issue:
- 1
- Pages:
- 112-119
- Publication date:
- 2020-05-18
- Acceptance date:
- 2020-03-25
- DOI:
- EISSN:
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1476-1645
- ISSN:
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0002-9637
- Pmid:
-
32431270
- Language:
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English
- Keywords:
- Pubs id:
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1106034
- Local pid:
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pubs:1106034
- Deposit date:
-
2020-06-22
Terms of use
- Copyright holder:
- American Society of Tropical Medicine and Hygiene
- Copyright date:
- 2020
- Rights statement:
- © The American Society of Tropical Medicine and Hygiene. This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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