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Smooth muscle cells in human atherosclerotic plaques express the fractalkine receptor CX3CR1 and undergo chemotaxis to the CX3C chemokine fractalkine (CX3CL1).

Abstract:

BACKGROUND: Chemokines are important mediators of inflammatory cell recruitment that play a significant role in atherosclerosis. Fractalkine (CX3CL1) is an unusual membrane-bound chemokine that mediates chemotaxis through the CX3CR1 receptor. Recently, functional polymorphisms in the human CX3CR1 gene have been described that are associated with coronary artery disease. METHODS AND RESULTS: We investigated the expression of the CX3C chemokine fractalkine and its receptor CX3CR1 in human coro...

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Publication status:
Published

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Authors


Bursill, C More by this author
Sadowski, J More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
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Journal:
Circulation
Volume:
108
Issue:
20
Pages:
2498-2504
Publication date:
2003-11-05
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
URN:
uuid:a6531dbd-4e01-443b-b5e4-4a6425c8320c
Source identifiers:
22711
Local pid:
pubs:22711

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