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Co-transcriptional RNA cleavage provides a failsafe termination mechanism for yeast RNA polymerase I.

Abstract:

Ribosomal RNA, transcribed by RNA polymerase (Pol) I, accounts for most cellular RNA. Since Pol I transcribes rDNA repeats with high processivity and polymerase density, transcription termination is a critical process. Early in vitro studies proposed polymerase pausing by Reb1 and transcript release at the T-rich element T1 determined transcription termination. However recent in vivo studies revealed a 'torpedo' mechanism for Pol I termination: co-transcriptional RNA cleavage by Rnt1 provides...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gkq894

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More from this funder
Funding agency for:
Proudfoot, NJ
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic acids research Journal website
Volume:
39
Issue:
4
Pages:
1439-1448
Publication date:
2011-03-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:a6367b23-2651-44d4-93b0-376e965d0c36
Source identifiers:
90817
Local pid:
pubs:90817

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