Co-transcriptional RNA cleavage provides a failsafe termination mechanism for yeast RNA polymerase I.
Ribosomal RNA, transcribed by RNA polymerase (Pol) I, accounts for most cellular RNA. Since Pol I transcribes rDNA repeats with high processivity and polymerase density, transcription termination is a critical process. Early in vitro studies proposed polymerase pausing by Reb1 and transcript release at the T-rich element T1 determined transcription termination. However recent in vivo studies revealed a 'torpedo' mechanism for Pol I termination: co-transcriptional RNA cleavage by Rnt1 provides...Expand abstract
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- Priscilla Braglia, Junya Kawauchi and Nick J. Proudfoot
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- Copyright © 2010 Priscilla Braglia, Junya Kawauchi and Nick J. Proudfoot. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.