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Journal article

Viral escape from neutralizing antibodies in early subtype A HIV-1 infection drives an increase in autologous neutralization breadth.

Abstract:

Antibodies that neutralize (nAbs) genetically diverse HIV-1 strains have been recovered from a subset of HIV-1 infected subjects during chronic infection. Exact mechanisms that expand the otherwise narrow neutralization capacity observed during early infection are, however, currently undefined. Here we characterized the earliest nAb responses in a subtype A HIV-1 infected Rwandan seroconverter who later developed moderate cross-clade nAb breadth, using (i) envelope (Env) glycoproteins from th...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.1003173

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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Pathog Journal website
Volume:
9
Issue:
2
Pages:
Article: e1003173
Publication date:
2013-02-05
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
URN:
uuid:a632f1b3-f247-47eb-ab0a-4eb5b2ac0f1b
Source identifiers:
387767
Local pid:
pubs:387767

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