- Abstract:
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Antibodies that neutralize (nAbs) genetically diverse HIV-1 strains have been recovered from a subset of HIV-1 infected subjects during chronic infection. Exact mechanisms that expand the otherwise narrow neutralization capacity observed during early infection are, however, currently undefined. Here we characterized the earliest nAb responses in a subtype A HIV-1 infected Rwandan seroconverter who later developed moderate cross-clade nAb breadth, using (i) envelope (Env) glycoproteins from th...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 2.3MB)
-
- Publisher copy:
- 10.1371/journal.ppat.1003173
-
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Pathog Journal website
- Volume:
- 9
- Issue:
- 2
- Pages:
- Article: e1003173
- Publication date:
- 2013-02-05
- DOI:
- EISSN:
-
1553-7374
- ISSN:
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1553-7366
- URN:
-
uuid:a632f1b3-f247-47eb-ab0a-4eb5b2ac0f1b
- Source identifiers:
-
387767
- Local pid:
- pubs:387767
- Language:
- English
- Keywords:
- Copyright holder:
- Murphy et al.
- Copyright date:
- 2013
- Notes:
- © 2013 Murphy et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
Viral escape from neutralizing antibodies in early subtype A HIV-1 infection drives an increase in autologous neutralization breadth.
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