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Targeting early changes in the synovial microenvironment: a new class of immunomodulatory therapy?

Abstract:
Objectives: Controlled immune responses rely on integrated crosstalk between cells and their microenvironment. We investigated whether targeting proinflammatory signals from the extracellular matrix that persist during pathological inflammation provides a viable strategy to treat rheumatoid arthritis (RA). Methods: Monoclonal antibodies recognising the fibrinogen-like globe (FBG) of tenascin-C were generated by phage display. Clones that neutralised FBG acti... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1136/annrheumdis-2018-214294

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
KIR
Cartwright, A More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
KIR
Marshall, J More by this author
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Grant:
to SRA, AJC, FC and JLM
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Grant:
Fellowship 20003: AS and KSM
Publisher:
BMJ Publishing Group Publisher's website
Journal:
Annals of the Rheumatic Diseases Journal website
Publication date:
2018-12-14
Acceptance date:
2018-11-20
DOI:
EISSN:
1468-2060
ISSN:
0003-4967
Pubs id:
pubs:944818
URN:
uri:a6232d90-2339-42c4-91f3-06b05bce710b
UUID:
uuid:a6232d90-2339-42c4-91f3-06b05bce710b
Local pid:
pubs:944818

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