Journal article
Targeting early changes in the synovial microenvironment: a new class of immunomodulatory therapy?
- Abstract:
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Objectives: Controlled immune responses rely on integrated crosstalk between cells and their microenvironment. We investigated whether targeting proinflammatory signals from the extracellular matrix that persist during pathological inflammation provides a viable strategy to treat rheumatoid arthritis (RA). Methods: Monoclonal antibodies recognising the fibrinogen-like globe (FBG) of tenascin-C were generated by phage display. Clones that neutralised FBG acti... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 1.4MB, Terms of use)
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- Publisher copy:
- 10.1136/annrheumdis-2018-214294
Authors
Funding
Bibliographic Details
- Publisher:
- BMJ Publishing Group
- Journal:
- Annals of the Rheumatic Diseases More from this journal
- Publication date:
- 2018-12-14
- Acceptance date:
- 2018-11-20
- DOI:
- EISSN:
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1468-2060
- ISSN:
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0003-4967
Item Description
- Keywords:
- Pubs id:
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pubs:944818
- UUID:
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uuid:a6232d90-2339-42c4-91f3-06b05bce710b
- Local pid:
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pubs:944818
- Deposit date:
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2018-11-21
Terms of use
- Copyright holder:
- Aungier et al
- Copyright date:
- 2018
- Notes:
- This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made.
- Licence:
- CC Attribution (CC BY)
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