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Journal article

Effect of a 2-week interruption in methotrexate treatment versus continued treatment on COVID-19 booster vaccine immunity in adults with inflammatory conditions (VROOM study): a randomised, open label, superiority trial

Abstract:

Background

Immunosuppressive treatments inhibit vaccine-induced immunity against SARS-CoV-2. We evaluated whether a 2-week interruption of methotrexate treatment immediately after the COVID-19 vaccine booster improved antibody responses against the S1 receptor-binding domain (S1-RBD) of the SARS-CoV-2 spike protein compared with uninterrupted treatment in patients with immune-mediated inflammatory diseases.

Methods

We did an open-label, prospec... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/S2213-2600(22)00186-2

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author

Contributors

Publisher:
Elsevier Publisher's website
Journal:
Lancet Respiratory Medicine Journal website
Publication date:
2022-06-27
Acceptance date:
2022-05-16
DOI:
ISSN:
2213-2600
Language:
English
Keywords:
Pubs id:
1263680
Local pid:
pubs:1263680
Deposit date:
2022-06-14

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