Effect of a 2-week interruption in methotrexate treatment versus continued treatment on COVID-19 booster vaccine immunity in adults with inflammatory conditions (VROOM study): a randomised, open label, superiority trial

Abhishek, A; Boyton, RJ; Peckham, N; McKnight, Á; Coates, LC; Bluett, J; Barber, V; Cureton, L; Francis, A; Appelbe, D; Eldridge, L; Julier, P; Valdes, AM; Brooks, T; Rombach, I; Altmann, DM; Nguyen-Van-Tam, JS; Williams, HC; Cook, JA

Journal article

Effect of a 2-week interruption in methotrexate treatment versus continued treatment on COVID-19 booster vaccine immunity in adults with inflammatory conditions (VROOM study): a randomised, open label, superiority trial

Abstract:: Background
Immunosuppressive treatments inhibit vaccine-induced immunity against SARS-CoV-2. We evaluated whether a 2-week interruption of methotrexate treatment immediately after the COVID-19 vaccine booster improved antibody responses against the S1 receptor-binding domain (S1-RBD) of the SARS-CoV-2 spike protein compared with uninterrupted treatment in patients with immune-mediated inflammatory diseases.
Methods
We did an open-label, prospec... Expand abstract
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Abhishek, A., Boyton, R. J., Peckham, N., McKnight, Á., Coates, L. C., Bluett, J., Barber, V., Cureton, L., Francis, A., Appelbe, D., Eldridge, L., Julier, P., Valdes, A. M., Brooks, T., Rombach, I., Altmann, D. M., Nguyen-Van-Tam, J. S., Williams, H. C., & Cook, J. A. (2022). Effect of a 2-week interruption in methotrexate treatment versus continued treatment on COVID-19 booster vaccine immunity in adults with inflammatory conditions (VROOM study): a randomised, open label, superiority trial. Lancet Respiratory Medicine, 10(9), 840–850.

MLA Style

Abhishek, A., et al. “Effect of a 2-Week Interruption in Methotrexate Treatment versus Continued Treatment on COVID-19 Booster Vaccine Immunity in Adults with Inflammatory Conditions (VROOM Study): a Randomised, Open Label, Superiority Trial.” Lancet Respiratory Medicine, vol. 10, no. 9, Elsevier, 2022, pp. 840–50.

Chicago Style

Abhishek, A, RJ Boyton, N Peckham, Á McKnight, LC Coates, J Bluett, V Barber, et al. 2022. “Effect of a 2-Week Interruption in Methotrexate Treatment versus Continued Treatment on COVID-19 Booster Vaccine Immunity in Adults with Inflammatory Conditions (VROOM Study): a Randomised, Open Label, Superiority Trial.” Lancet Respiratory Medicine 10 (9): 840–50.
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