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A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling.

Abstract:

Lysine methylation of histones is recognized as an important component of an epigenetic indexing system demarcating transcriptionally active and inactive chromatin domains. Trimethylation of histone H3 lysine 4 (H3K4me3) marks transcription start sites of virtually all active genes. Recently, we reported that the WD40-repeat protein WDR5 is important for global levels of H3K4me3 and control of HOX gene expression. Here we show that a plant homeodomain (PHD) finger of nucleosome remodelling fa...

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Publication status:
Published

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Publisher copy:
10.1038/nature04815

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Journal:
Nature
Volume:
442
Issue:
7098
Pages:
86-90
Publication date:
2006-07-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:a6080550-6947-4dde-bcdc-100ef5be70f5
Source identifiers:
331915
Local pid:
pubs:331915

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