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Deep brain stimulation and levodopa affect gait variability in Parkinson disease differently

Abstract:

Background Both dopaminergic medication and subthalamic nucleus (STN) deep brain stimulation (DBS) can improve the amplitude and speed of gait in Parkinson disease (PD), but relatively little is known about their comparative effects on gait variability. Gait irregularity has been linked to the degeneration of cholinergic neurons in the pedunculopontine nucleus (PPN). Objectives The STN and PPN have reciprocal connections, and we hypothesized that STN DBS might improve gait variability by mod...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.neurom.2022.04.035

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Publisher:
Elsevier
Journal:
Neuromodulation More from this journal
Volume:
26
Issue:
2
Pages:
382-393
Publication date:
2022-05-11
Acceptance date:
2022-02-06
DOI:
EISSN:
1525-1403
ISSN:
1094-7159
Language:
English
Keywords:
Pubs id:
1248985
Local pid:
pubs:1248985
Deposit date:
2022-05-12

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