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Broad-scale recombination patterns underlying proper disjunction in humans.

Abstract:

Although recombination is essential to the successful completion of human meiosis, it remains unclear how tightly the process is regulated and over what scale. To assess the nature and stringency of constraints on human recombination, we examined crossover patterns in transmissions to viable, non-trisomic offspring, using dense genotyping data collected in a large set of pedigrees. Our analysis supports a requirement for one chiasma per chromosome rather than per arm to ensure proper disjunct...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pgen.1000658

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
5
Issue:
9
Pages:
Article: e1000658
Publication date:
2009-09-05
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:a59b2f61-d461-4260-9ffa-43912841ad65
Source identifiers:
69646
Local pid:
pubs:69646

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