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Broad-scale recombination patterns underlying proper disjunction in humans.

Abstract:

Although recombination is essential to the successful completion of human meiosis, it remains unclear how tightly the process is regulated and over what scale. To assess the nature and stringency of constraints on human recombination, we examined crossover patterns in transmissions to viable, non-trisomic offspring, using dense genotyping data collected in a large set of pedigrees. Our analysis supports a requirement for one chiasma per chromosome rather than per arm to ensure proper disjunct...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pgen.1000658

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
5
Issue:
9
Article number:
e1000658
Publication date:
2009-09-01
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Source identifiers:
69646
Language:
English
Keywords:
UUID:
uuid:a59b2f61-d461-4260-9ffa-43912841ad65
Local pid:
pubs:69646
Deposit date:
2012-12-19

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