Journal article
OrthoFinder: solving fundamental biases in whole genome comparisons dramatically improves orthogroup inference accuracy.
- Abstract:
- Identifying homology relationships between sequences is fundamental to biological research. Here we provide a novel orthogroup inference algorithm called OrthoFinder that solves a previously undetected gene length bias in orthogroup inference, resulting in significant improvements in accuracy. Using real benchmark datasets we demonstrate that OrthoFinder is more accurate than other orthogroup inference methods by between 8 % and 33 %. Furthermore, we demonstrate the utility of OrthoFinder by providing a complete classification of transcription factor gene families in plants revealing 6.9 million previously unobserved relationships.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 1.4MB, Terms of use)
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- Publisher copy:
- 10.1186/s13059-015-0721-2
Authors
- Publisher:
- BioMed Central
- Journal:
- Genome biology More from this journal
- Volume:
- 16
- Issue:
- 1
- Pages:
- 157
- Publication date:
- 2015-01-01
- DOI:
- EISSN:
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1474-760X
- ISSN:
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1474-7596
- Language:
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English
- Pubs id:
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pubs:536611
- UUID:
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uuid:a5832e69-43bb-4790-9940-061a001e2b9b
- Local pid:
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pubs:536611
- Source identifiers:
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536611
- Deposit date:
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2015-11-16
- ARK identifier:
Terms of use
- Copyright holder:
- Emms and Kelly
- Copyright date:
- 2015
- Notes:
-
Copyright © 2015 Emms and Kelly.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Licence:
- CC Attribution (CC BY)
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