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OrthoFinder: solving fundamental biases in whole genome comparisons dramatically improves orthogroup inference accuracy.

Abstract:

Identifying homology relationships between sequences is fundamental to biological research. Here we provide a novel orthogroup inference algorithm called OrthoFinder that solves a previously undetected gene length bias in orthogroup inference, resulting in significant improvements in accuracy. Using real benchmark datasets we demonstrate that OrthoFinder is more accurate than other orthogroup inference methods by between 8 % and 33 %. Furthermore, we demonstrate the utility of OrthoFinder by ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s13059-015-0721-2

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Plant Sciences
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Plant Sciences
Bill and Melinda Gates Foundation More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Genome biology Journal website
Volume:
16
Issue:
1
Pages:
157
Publication date:
2015
DOI:
EISSN:
1474-760X
ISSN:
1474-7596
URN:
uuid:a5832e69-43bb-4790-9940-061a001e2b9b
Source identifiers:
536611
Local pid:
pubs:536611
Language:
English

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