Journal article
Prevalence of psoriatic arthritis in patients with psoriasis: A systematic review and meta-analysis of observational and clinical studies
- Abstract:
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Background
Wide-ranging prevalence estimates of psoriatic arthritis (PsA) in patients with psoriasis have been reported.
Objectives
To assess the prevalence and incidence of PsA in patients with psoriasis.
Methods
Two authors independently searched three databases for studies reporting on the prevalence or incidence of PsA in patients with psoriasis. A proportion meta-analysis was performed to calculate the pooled proportion estimates of PsA in patients with psoriasis.
Results
A total of 266 studies were included, examining 976,408 patients with psoriasis. Overall, the pooled proportion (95% confidence interval) of PsA among patients with psoriasis was 19.7% (18.5%-20.9%). In children and adolescents (<18 years), the pooled prevalence was 3.3% (2.1%-4.9%). The PsA prevalence was 22.7% (20.6%-25.0%) in European, 21.5% (15.4%-28.2%) South American, 19.5% (17.1%-22.1%) North American, 15.5% (0.009%-51.5%) African, and 14.0% (11.7%-16.3%) in Asian psoriasis patients. The prevalence of PsA was 23.8% (20.1%-27.6%) in studies where the ClASsification criteria for Psoriatic ARthritis (CASPAR) was applied. The incidence of PsA among psoriasis patients ranged from 0.27 to 2.7 per 100 person-years.
Limitations
Between-study heterogeneity may have affected the estimates.
Conclusions
We found that one in five patients with psoriasis have PsA. With the growing recognition of CASPAR, more homogenous and comparable prevalence estimates are expected to be reported.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 579.7KB, Terms of use)
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- Publisher copy:
- 10.1016/j.jaad.2018.06.027
Authors
- Publisher:
- Elsevier
- Journal:
- Journal of the American Academy of Dermatology More from this journal
- Volume:
- 80
- Issue:
- 1
- Pages:
- 251-265
- Publication date:
- 2018-06-18
- Acceptance date:
- 2018-06-10
- DOI:
- EISSN:
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1097-6787
- ISSN:
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0190-9622
- Keywords:
- Pubs id:
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pubs:854381
- UUID:
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uuid:a56d216f-13c4-457b-8b32-6a0aaf3dabcf
- Local pid:
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pubs:854381
- Source identifiers:
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854381
- Deposit date:
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2018-06-01
Terms of use
- Copyright holder:
- American Academy of Dermatology
- Copyright date:
- 2018
- Notes:
- © 2018 by the American Academy of Dermatology, Inc. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.jaad.2018.06.027
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