Comparison of multiparametric magnetic resonance imaging and targeted biopsy with systematic biopsy alone for the diagnosis of prostate cancer: A systematic review and meta-analysis

Journal article

IMPORTANCE

The current diagnostic pathway for patients with suspected prostate cancer (PCa) includes prostate biopsy. A large proportion of individuals who undergo biopsy have either no PCa or low-risk disease that does not require treatment. Unnecessary biopsies may potentially be avoided with prebiopsy imaging.

OBJECTIVE

To compare the performance of systematic transrectal ultrasonography–guided prostate biopsy vs prebiopsy biparametric or multiparametric magnetic resonance imaging (MRI) followed by targeted biopsy with or without systematic biopsy.

DATA SOURCES

MEDLINE, Embase, Cochrane, Web of Science, clinical trial registries, and reference lists of recent reviews were searched through December 2018 for randomized clinical trials using the terms “prostate cancer” and “MRI.”

STUDY SELECTION

Randomized clinical trials comparing diagnostic pathways including prebiopsy MRI vs systematic transrectal ultrasonography–guided biopsy in biopsy-naive men with a clinical suspicion of PCa.

DATA EXTRACTION AND SYNTHESIS

Data were pooled using random-effects meta-analysis. Risk of bias was assessed using the revised Cochrane tool. Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines were followed. All review stages were conducted by 2 reviewers.

MAIN OUTCOMES AND MEASURES

Detection rate of clinically significant and insignificant PCa, number of biopsy procedures, number of biopsy cores taken, and complications.

RESULTS

Seven high-quality trials (2582 patients) were included. Compared with systematic transrectal ultrasonography–guided biopsy alone, MRI with or without targeted biopsy was associated with a 57% (95% CI, 2%-141%) improvement in the detection of clinically significant PCa, a 33% (95% CI, 23%-45%) potential reduction in the number of biopsy procedures, and a 77% (95% CI, 60%-93%) reduction in the number of cores taken per procedure. One trial showed reduced pain and bleeding adverse effects. Systematic sampling of the prostate in addition to the acquisition of targeted cores did not significantly improve the detection of clinically significant PCa compared with systematic biopsy alone.

Authors: Elwenspoek, M; Sheppard, A; McInnes, M; Merriel, S; Rowe, E

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: JAMA Network
• Journal: JAMA Network Open
• Volume: 2
• Issue: 8
• Pages: e198427
• Publication date: 2019-08-01
• Acceptance date: 2019-06-11
• DOI: 10.1001/jamanetworkopen.2019.8427
• EISSN: 2574-3805
• Pmid: 31390032
• Language: English