Does ondansetron attenuate amphetamine-induced behaviour in human volunteers?

Journal article

The effect of the 5-HT3 receptor antagonist, ondansetron, on the decrease in hunger produced by amphetamine was assessed in nine male volunteers using a double-blind cross-over design. Amphetamine (15 mg orally) produced a significant decrease in self-ratings of hunger 2.5 h after administration. This effect was significantly attenuated by pre-treatment with ondansetron (12 mg orally over 24 h). These findings in humans are consistent with data from animal studies suggesting that ondansetron can attenuate certain catecholamins-mediated behaviours produced by amphetamine. However, explanations founded on pharmacokinetic factors cannot be presently excluded.

Authors: Silverstone, P; Johnson, B; Cowen, P

• Publication status: Published
• Journal: Psychopharmacology
• Volume: 107
• Issue: 1
• Pages: 140-141
• Publication date: 1992-01-01
• DOI: 10.1007/bf02244979
• EISSN: 1432-2072
• ISSN: 0033-3158
• Language: English
• Keywords: Humans; Middle Aged; Behavior; Adult; Male; Imidazoles; Reference Values; Hunger; Amphetamine; Serotonin Antagonists; Ondansetron