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Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia.

Abstract:

The serological analysis of recombinant cDNA expression libraries (SEREX) technique was used to immunoscreen a testes cDNA expression library with sera from newly diagnosed acute myeloid leukaemia (AML) patients. We used a testis cDNA library to aid our identification of cancer-testis (CT) antigens. We identified 44 antigens which we further immunoscreened with sera from AML, chronic myeloid leukaemia (CML), and normal donors. Eight antigens were solely recognised by patient sera including th...

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Publisher copy:
10.1016/j.bbrc.2005.08.024

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Journal:
Biochemical and biophysical research communications
Volume:
335
Issue:
4
Pages:
1293-1304
Publication date:
2005-10-05
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:a542861c-b30f-43d1-86f0-86bfaf9b5561
Source identifiers:
246401
Local pid:
pubs:246401

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