Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.

Journal article

Lymphatic vessels develop from specialized endothelial cells in preexisting blood vessels, but the molecular signals that regulate this separation are unknown. Here we identify a failure to separate emerging lymphatic vessels from blood vessels in mice lacking the hematopoietic signaling protein SLP-76 or Syk. Blood-lymphatic connections lead to embryonic hemorrhage and arteriovenous shunting. Expression of slp-76 could not be detected in endothelial cells, and blood-filled lymphatics also ar...

Expand abstract

Authors: Abtahian, F; Guerriero, A; Sebzda, E; Lu, M; Zhou, R

• Publication status: Published
• Journal: Science (New York, N.Y.)
• Volume: 299
• Issue: 5604
• Pages: 247-251
• Publication date: 2003-01-01
• DOI: 10.1126/science.1079477
• EISSN: 1095-9203
• ISSN: 0036-8075
• Language: English
• Keywords: Intestines; Dextrans; Endothelium, Vascular; Bone Marrow Cells; Glycoproteins; Veins; Vascular Endothelial Growth Factor Receptor-3; Bone Marrow Transplantation; Adaptor Proteins, Signal Transducing; Intracellular Signaling Peptides and Proteins; Signal Transduction; Animals, Newborn; Lymphatic System; Tumor Suppressor Proteins; Enzyme Precursors; Fluorescein-5-isothiocyanate; Endothelium, Lymphatic; Stem Cells; Homeodomain Proteins; Mice; Mesenteric Arteries; Antigens, CD34; Hemorrhage; Animals; Blood Vessels; Mesenteric Veins; Protein-Tyrosine Kinases; Phosphoproteins