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Journal article

Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis.

Abstract:

The c-Jun N-terminal kinase (JNK) signaling pathway plays a critical role in mediating apoptosis in the nervous system; however, the mechanisms by which JNK triggers neuronal apoptosis remain incompletely understood. Recent studies suggest that in addition to inducing transcription of pro-apoptotic genes, JNK also directly activates the cell death machinery. Here, we report that JNK catalyzed the phosphorylation of the BH3-only protein Bcl-2 interacting mediator of cell death (BimEL) at serin...

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Publication status:
Published

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Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
24
Issue:
40
Pages:
8762-8770
Publication date:
2004-10-05
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:a530a4bd-c331-4c57-a1fe-27eabb218022
Source identifiers:
248015
Local pid:
pubs:248015

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