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Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1 alpha localization in erythroblasts

Abstract:

Congenital dyserythropoietic anemia type 1 (CDA-1), a rare inborn anemia characterized by abnormal chromatin ultrastructure in erythroblasts, is caused by abnormalities in codanin-1, a highly conserved protein of unknown function. We have produced 3 monoclonal antibodies to codanin-1 that demonstrate its distribution in both nucleus and cytoplasm by immunofluorescence and allow quantitative measurements of patient and normal material byWestern blot.Adetailed analysis of chromatin structure in...

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Publication status:
Published

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Journal:
BLOOD
Volume:
117
Issue:
25
Pages:
6928-6938
Publication date:
2011-06-23
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:a4dbfb43-e843-46fa-b856-a4e6499352ff
Source identifiers:
164263
Local pid:
pubs:164263
Language:
English

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