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Journal article

Effect of vaccine dose on the safety and immunogenicity of a candidate TB vaccine, MVA85A, in BCG vaccinated UK adults.

Abstract:

PURPOSE: A non-randomised, open-label, Phase I safety and immunogenicity dose-finding study to assess the safety and immunogenicity of the candidate TB vaccine Modified Vaccinia virus Ankara expressing Antigen 85A (MVA85A) from Mycobacterium tuberculosis (MTB) in healthy adult volunteers previously vaccinated with BCG. METHODS: Healthy BCG-vaccinated volunteers were vaccinated with either 1×10(7) or 1×10(8)PFU of MVA85A. All adverse events were documented and antigen specific T cell responses...

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Publication status:
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Authors


Pathan, AA More by this author
Minassian, AM More by this author
Sander, CR More by this author
Rowland, R More by this author
Porter, DW More by this author
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Journal:
Vaccine
Volume:
30
Issue:
38
Pages:
5616-5624
Publication date:
2012-08-05
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:a4d87625-5a10-4727-90bc-b51411691a24
Source identifiers:
342310
Local pid:
pubs:342310

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