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Interleukin-1 acts via the JNK-2 signaling pathway to induce aggrecan degradation by human chondrocytes

Abstract:

Objective: Aggrecan enables articular cartilage to bear load and resist compression. Aggrecan loss occurs early in osteoarthritis and rheumatoid arthritis and can be induced by inflammatory cytokines such as interleukin‐1 (IL‐1). IL‐1 induces cleavage of specific aggrecans characteristic of the ADAMTS proteinases. The aim of this study was to identify the intracellular signaling pathways by which IL‐1 causes aggrecan... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/art.39099

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
Kennedy Trust for Rheumatology Research More from this funder
Publisher:
Wiley Publisher's website
Journal:
Arthritis and Rheumatology Journal website
Volume:
67
Issue:
7
Pages:
1826-1836
Publication date:
2015-06-26
Acceptance date:
2015-02-26
DOI:
EISSN:
2326-5205
ISSN:
2326-5191
Source identifiers:
510362

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