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Interleukin-1 acts via the JNK-2 signaling pathway to induce aggrecan degradation by human chondrocytes

Abstract:

Objective: Aggrecan enables articular cartilage to bear load and resist compression. Aggrecan loss occurs early in osteoarthritis and rheumatoid arthritis and can be induced by inflammatory cytokines such as interleukin‐1 (IL‐1). IL‐1 induces cleavage of specific aggrecans characteristic of the ADAMTS proteinases. The aim of this study was to identify the intracellular signaling pathways by which IL‐1 causes aggrecan... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/art.39099

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More from this funder
Name:
Arthritis Research UK
Grant:
20563
More from this funder
Name:
National Institutes of Health
Grant:
AR-40994
More from this funder
Name:
Kennedy Trust for Rheumatology Research
Publisher:
Wiley
Journal:
Arthritis and Rheumatology More from this journal
Volume:
67
Issue:
7
Pages:
1826-1836
Publication date:
2015-06-26
Acceptance date:
2015-02-26
DOI:
EISSN:
2326-5205
ISSN:
2326-5191
Language:
English
Keywords:
Pubs id:
pubs:510362
UUID:
uuid:a4d7c9d4-8d4d-44fa-a473-018f3ddfbbde
Local pid:
pubs:510362
Source identifiers:
510362
Deposit date:
2016-01-28

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