Journal article
Progress towards a public chemogenomic set for protein kinases and a call for contributions.
- Abstract:
- Protein kinases are highly tractable targets for drug discovery. However, the biological function and therapeutic potential of the majority of the 500+ human protein kinases remains unknown. We have developed physical and virtual collections of small molecule inhibitors, which we call chemogenomic sets, that are designed to inhibit the catalytic function of almost half the human protein kinases. In this manuscript we share our progress towards generation of a comprehensive kinase chemogenomic set (KCGS), release kinome profiling data of a large inhibitor set (Published Kinase Inhibitor Set 2 (PKIS2)), and outline a process through which the community can openly collaborate to create a KCGS that probes the full complement of human protein kinases.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 7.7MB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pone.0181585
Authors
- Publisher:
- Public Library of Science
- Journal:
- PLoS One More from this journal
- Volume:
- 12
- Issue:
- 8
- Pages:
- e0181585
- Publication date:
- 2017-08-01
- Acceptance date:
- 2017-07-03
- DOI:
- EISSN:
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1932-6203
- Language:
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English
- Keywords:
- Pubs id:
-
pubs:713303
- UUID:
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uuid:a4c663ba-4071-41bc-8aaf-03f807957ab9
- Local pid:
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pubs:713303
- Source identifiers:
-
713303
- Deposit date:
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2017-08-11
- ARK identifier:
Terms of use
- Copyright holder:
- Drewry et al
- Copyright date:
- 2017
- Notes:
- © 2017 Drewry et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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