- Abstract:
-
UNLABELLED: Carbonyl reduction constitutes a phase I reaction for many xenobiotics and is carried out in mammals mainly by members of two protein families, namely aldo-keto reductases and short-chain dehydrogenases/reductases. In addition to their capacity to reduce xenobiotics, several of the enzymes act on endogenous compounds such as steroids or eicosanoids. One of the major carbonyl reducing enzymes found in humans is carbonyl reductase 1 (CBR1) with a very broad substrate spectrum. A par...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
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(pdf, 485.2kb)
-
- Publisher copy:
- 10.1371/journal.pone.0007113
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS one Journal website
- Volume:
- 4
- Issue:
- 10
- Pages:
- Article: e7113
- Publication date:
- 2009
- DOI:
- EISSN:
-
1932-6203
- ISSN:
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1932-6203
- URN:
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uuid:a47e1c7e-5c09-4a8b-bb64-a5545199bf35
- Source identifiers:
-
107476
- Local pid:
- pubs:107476
- Copyright holder:
- Pilka et al.
- Copyright date:
- 2009
- Notes:
- Copyright 2009 Pilka et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
Structural basis for substrate specificity in human monomeric carbonyl reductases.
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