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Structural basis for substrate specificity in human monomeric carbonyl reductases.

Abstract:

UNLABELLED: Carbonyl reduction constitutes a phase I reaction for many xenobiotics and is carried out in mammals mainly by members of two protein families, namely aldo-keto reductases and short-chain dehydrogenases/reductases. In addition to their capacity to reduce xenobiotics, several of the enzymes act on endogenous compounds such as steroids or eicosanoids. One of the major carbonyl reducing enzymes found in humans is carbonyl reductase 1 (CBR1) with a very broad substrate spectrum. A par...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0007113

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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
El-Hawari, Y More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Structural Genomics Consortium More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
4
Issue:
10
Pages:
Article: e7113
Publication date:
2009
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:a47e1c7e-5c09-4a8b-bb64-a5545199bf35
Source identifiers:
107476
Local pid:
pubs:107476

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