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A novel fast strategy to calculate equieffective doses under different dose rate conditions

Abstract:
Background
Radiopharmaceutical therapy (RPT) has gained notable attention for its potential in treating difficult cancers, with [177Lu]Lu-DOTATATE being a notable example. However, the radiobiology of RPT is less understood compared to external beam radiotherapy (EBRT), and dosimetry protocols are not standardized. Organ dose limits and tumor dose-response correlations are often based on radiobiologically motivated equieffective doses (EQDX). On top of absorbed ... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1002/mp.17688

Authors

More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
ORCID:
0009-0008-1138-5715
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
ORCID:
0000-0003-4672-5683
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Oxford college:
Keble College
Role:
Author
ORCID:
0000-0002-6880-5687


More from this funder
Funder identifier:
https://ror.org/054225q67
Grant:
28684


Publisher:
Wiley
Journal:
Medical Physics More from this journal
Volume:
52
Issue:
5
Pages:
3416-3427
Publication date:
2025-02-15
Acceptance date:
2025-02-03
DOI:
EISSN:
2473-4209
ISSN:
0094-2405


Language:
English
Keywords:
Pubs id:
2085997
Local pid:
pubs:2085997
Deposit date:
2025-02-17
ARK identifier:

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