Characterization of fission yeast cohesin: essential anaphase proteolysis of Rad21 phosphorylated in the S phase.

Journal article

Cohesin complex acts in the formation and maintenance of sister chromatid cohesion during and after S phase. Budding yeast Scc1p/Mcd1p, an essential subunit, is cleaved and dissociates from chromosomes in anaphase, leading to sister chromatid separation. Most cohesin in higher eukaryotes, in contrast, is dissociated from chromosomes well before anaphase. The universal role of cohesin during anaphase thus remains to be determined. We report here initial characterization of four putative cohesi...

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Authors: Tomonaga, T; Nagao, K; Kawasaki, Y; Furuya, K; Murakami, A

• Publication status: Published
• Journal: Genes and development
• Volume: 14
• Issue: 21
• Pages: 2757-2770
• Publication date: 2000-11-01
• DOI: 10.1101/gad.832000
• EISSN: 1549-5477
• ISSN: 0890-9369
• Language: English
• Keywords: Chromosomal Proteins, Non-Histone; Centromere; Fungal Proteins; Chromosomes, Fungal; Gene Targeting; Macromolecular Substances; S Phase; Phosphorylation; Cell Cycle Proteins; Protein Processing, Post-Translational; Nuclear Proteins; Phosphoproteins; Schizosaccharomyces; Genes, Fungal; Anaphase; Protein Subunits; Schizosaccharomyces pombe Proteins