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Model scenarios for switch-like mitotic transitions.

Abstract:

To facilitate rapid accumulation of Cdk1-phosphorylated substrate proteins, the Cdk1 counter-acting phosphatase, PP2A-B55 is inhibited during M phase by stoichiometric inhibitors (ENSA and Arpp19). These inhibitors are activated when phosphorylated by Cdk1-activated Greatwall-kinase. Recent experiments show that ENSA is dephosphorylated and inactivated by the PP2A-B55 itself, and acts as an unfair substrate inhibiting PP2A-B55 activity towards other Cdk1 substrates. Mathematical modelling sho...

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Publication status:
Published
Peer review status:
Peer Reviewed

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
EC’s Seventh Framework Programme More from this funder
Biotechnology and Biological Sciences Research Council More from this funder
Publisher:
Elsevier Publisher's website
Journal:
FEBS Letters Journal website
Volume:
589
Issue:
6
Pages:
667-671
Publication date:
2015-02-05
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:a42baca5-f229-44a1-a443-c98bee5d0903
Source identifiers:
508051
Local pid:
pubs:508051

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