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Journal article

Emerging roles of Meis1 in cardiac regeneration, stem cells, and cancer

Abstract:

Meis1 is a member of three-amino-acid loop extension (TALE) homeodomain transcription factors. Studies in the last decade have shown that Meis1 has crucial roles in cardiac regeneration, stem cell function, and tumorigenesis. We have recently demonstrated that knocking out of Meis1 in adult cardiomyocytes resulted in the induction of cardiomyocyte proliferation. This suggests that targeting of Meis1 might be utilized in the manipulation of cardiomyocyte cell cycle post cardiac injuries. In ad...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.2174/1389450118666170724165514

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM
Albayrak, E More by this author
Kocabaş, F More by this author
Science Academy’s Young Scientist Awards Program More from this funder
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Publisher:
Bentham Science Publishers Publisher's website
Journal:
Current Drug Targets Journal website
Volume:
18
Issue:
2
Pages:
181-190
Publication date:
2018-04-12
Acceptance date:
2017-07-13
DOI:
EISSN:
1873-5592
ISSN:
1389-4501
Pubs id:
pubs:730491
URN:
uri:a42563ea-f1dc-4af8-9816-e9b00f77b508
UUID:
uuid:a42563ea-f1dc-4af8-9816-e9b00f77b508
Local pid:
pubs:730491

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