Internet publication
MAIT cells protect against sterile lung injury
- Abstract:
- Mucosal-associated invariant T (MAIT) cells, the most abundant unconventional T cells in the lung, have been recently linked to tissue protection and repair. Their role, especially in sterile lung injury, is unknown. Using single cell RNA sequencing (scRNA-seq), spectral analysis and adoptive transfer in a bleomycin-induced sterile lung injury, we found that bleomycin activates murine pulmonary MAIT cells and induces an accompanying tissue repair programme, associated with a protective role against bleomycin-induced lung injury. MAIT cells drive the accumulation of type 1 conventional dendritic cells (cDC1), limiting tissue damage in a DNGR-1 dependent manner. Human scRNA-seq data revealed that MAIT cells were activated, with increased cDC populations in idiopathic pulmonary fibrosis patients. Thus, MAIT cells enhance defence against sterile lung injury by fostering cDC1-driven anti-fibrotic pathways.
- Publication status:
- Published
- Peer review status:
- Not peer reviewed
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(Preview, Author's original, pdf, 37.1MB, Terms of use)
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- Publisher copy:
- 10.1101/2024.01.08.574631
Authors
+ Wellcome Trust
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- Funder identifier:
- https://ror.org/029chgv08
- Grant:
- 104553/Z/14/Z
- 222426/Z/21/Z
- 211050/Z/18/Z
- Host title:
- bioRxiv
- Publication date:
- 2024-01-08
- DOI:
- Language:
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English
- Keywords:
- Pubs id:
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1602776
- Local pid:
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pubs:1602776
- Deposit date:
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2025-02-11
- ARK identifier:
Terms of use
- Copyright holder:
- Zhang et al
- Copyright date:
- 2024
- Rights statement:
- The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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