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Soluble IGF2 receptor rescues Apc(Min/+) intestinal adenoma progression induced by Igf2 loss of imprinting.

Abstract:

The potent growth-promoting activity of insulin-like growth factor-II (IGF-II) is highly regulated during development but frequently up-regulated in tumors. Increased expression of the normally monoallelic (paternally expressed) mouse (Igf2) and human (IGF2) genes modify progression of intestinal adenoma in the Apc(Min/+) mouse and correlate with a high relative risk of human colorectal cancer susceptibility, respectively. We examined the functional consequence of Igf2 allelic dosage (null, m...

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Publication status:
Published

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Authors


Foulstone, EJ More by this author
Pignatelli, M More by this author
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Journal:
Cancer research
Volume:
66
Issue:
4
Pages:
1940-1948
Publication date:
2006-02-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:a3fa9b4f-3fd4-42ac-a8c6-0834a70f7f5c
Source identifiers:
458574
Local pid:
pubs:458574

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