Journal article icon

Journal article

Facilitation by intracellular carbonic anhydrase of Na-HCO co-transport but not Na/H exchange activity in the mammalian ventricular myocyte

Abstract:

Carbonic anhydrase enzymes (CAs) catalyse the reversible hydration of CO to H and HCO ions. This catalysis is proposed to be harnessed by acid/base transporters, to facilitate their transmembrane flux activity, either through direct protein-protein binding (a 'transport metabolon') or local functional interaction. Flux facilitation has previously been investigated by heterologous co-expression of relevant proteins in host cell lines/oocytes. Here, we examine the influence of intrinsic CA act...

Expand abstract

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Role:
Author
Expand authors...
Journal:
Journal of Physiology
Volume:
592
Issue:
5
Pages:
991-1007
Publication date:
2014-03-01
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:a3d0117a-812c-48ff-847d-5e7cf934f8a9
Source identifiers:
452594
Local pid:
pubs:452594

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP