Combined effects of routine blood pressure lowering and intensive glucose control on macrovascular and microvascular outcomes in patients with type 2 diabetes: New results from the ADVANCE trial.

Journal article

OBJECTIVE: To assess the magnitude and independence of the effects of routine blood pressure lowering and intensive glucose control on clinical outcomes in patients with long-standing type 2 diabetes. RESEARCH DESIGN AND METHODS: This was a multicenter, factorial randomized trial of perindopril-indapamide versus placebo (double-blind comparison) and intensive glucose control with a gliclazide MR-based regimen (target A1C

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Authors: Zoungas, S; de Galan, B; Ninomiya, T; Grobbee, D; Hamet, P

• Journal: Diabetes care
• Volume: 32
• Issue: 11
• Pages: 2068-2074
• Publication date: 2009-11-01
• DOI: 10.2337/dc09-0959
• EISSN: 1935-5548
• ISSN: 0149-5992
• Language: English
• Keywords: Blood Glucose; Humans; Blood Pressure; Indapamide; Middle Aged; Hypoglycemic Agents; Drug Therapy, Combination; Albuminuria; Diabetic Angiopathies; Angiotensin-Converting Enzyme Inhibitors; Male; Antihypertensive Agents; Placebos; Gliclazide; Aged; Perindopril; ADVANCE Collaborative Group; Microcirculation; Drug Combinations; Female; Hypertension; Diabetes Mellitus, Type 2