Combined effects of routine blood pressure lowering and intensive glucose control on macrovascular and microvascular outcomes in patients with type 2 diabetes: New results from the ADVANCE trial.

Journal article

OBJECTIVE: To assess the magnitude and independence of the effects of routine blood pressure lowering and intensive glucose control on clinical outcomes in patients with long-standing type 2 diabetes. RESEARCH DESIGN AND METHODS: This was a multicenter, factorial randomized trial of perindopril-indapamide versus placebo (double-blind comparison) and intensive glucose control with a gliclazide MR-based regimen (target A1C 0.1): the separate effects of the two interventions for the renal outcomes and death appeared to be additive on the log scale. Compared with neither intervention, combination treatment reduced the risk of new or worsening nephropathy by 33% (95% CI 12-50%, P = 0.005), new onset of macroalbuminuria by 54% (35-68%, P < 0.0001), and new onset of microalbuminuria by 26% (17-34%). Combination treatment was associated with an 18% reduction in the risk of all-cause death (1-32%, P = 0.04). CONCLUSIONS: The effects of routine blood pressure lowering and intensive glucose control were independent of one another. When combined, they produced additional reductions in clinically relevant outcomes.

Authors: Zoungas, S; de Galan, B; Ninomiya, T; Grobbee, D; Hamet, P

• Journal: Diabetes care
• Volume: 32
• Issue: 11
• Pages: 2068-2074
• Publication date: 2009-11-01
• DOI: 10.2337/dc09-0959
• EISSN: 1935-5548
• ISSN: 0149-5992
• Language: English
• Keywords: Blood Glucose; Humans; Blood Pressure; Indapamide; Middle Aged; Hypoglycemic Agents; Drug Therapy, Combination; Albuminuria; Diabetic Angiopathies; Angiotensin-Converting Enzyme Inhibitors; Male; Antihypertensive Agents; Placebos; Gliclazide; Aged; Perindopril; ADVANCE Collaborative Group; Microcirculation; Drug Combinations; Female; Hypertension; Diabetes Mellitus, Type 2