Patent
Liposome treatment of viral infections
- Documentation:
- One can treat a viral infection such as hepatitis B (HBV), hepatitis C (HCV), and bovine viral diarrhea virus (BVDV) infections via the delivery of pH sensitive liposomes directly into the endoplasmic reticulum (ER) membrane. Two exemplary liposome formulations are DOPE/CHEMS (DC liposomes) and DOPE/CHEMS/PEG-PE (DCPP liposomes). DC and DCPP liposomes can optimize the intracellular delivery of N -butyl deoxynojirimycin (NB-DNJ), and consequently increase the in vivo activity of this iminosugar several orders of magnitude, and could be used in combination with other therapeutic agents such as interferon and/or ribavirin. The optimized release of N B-DNJ directly into the ER can be also applied for the treatment of other viruses, for which NB-DNJ is known to be an effective antiviral, such as human immunodeficiency virus (HIV).
- Publication status:
- Published
Actions
Authors
- Publisher:
- European Patent Office
- Journal:
- European Patent Office More from this journal
- Publication date:
- 2011-12-28
- Patent number:
-
EP2399587
- Application number:
- 11182414
- Patent status:
- Issued/granted
- Pubs id:
-
pubs:383425
- UUID:
-
uuid:a3ac1d57-211b-4cbe-83e2-ecf6db840218
- Local pid:
-
pubs:383425
- Source identifiers:
-
383425
- Deposit date:
-
2016-02-11
- ARK identifier:
Terms of use
- Copyright date:
- 2011
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