Journal article
Cell fate following irradiation of MDA-MB-231- and MCF-7 breast cancer cells pre-exposed to a tetrahydroisoquinoline sulfamate microtubule disruptor
- Abstract:
-
Atetrahydroisoquinoline (THIQ) core is able to mimic the A and B rings of 2-methoxyestradiol (2ME2), an endogenous estrogen metabolite that demonstrates promising anticancer properties primarily by disrupting microtubule dynamic instability parameters, but has very poor pharmaceutical properties that can be improved by sulfamoylation. The nonsteroidal THIQ-based microtubule disruptor 2-(3-bromo-4,5-dimethoxybenzyl)-7-methoxy-6-sulfamoyloxy-1,2,3,4-tetrahydro isoquinoline (STX3451), with enhan...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 5.5MB, Terms of use)
-
- Publisher copy:
- 10.3390/molecules27123819
Authors
Bibliographic Details
- Publisher:
- MDPI
- Journal:
- Molecules More from this journal
- Volume:
- 27
- Issue:
- 12
- Article number:
- 3819
- Publication date:
- 2022-06-14
- Acceptance date:
- 2022-05-30
- DOI:
- EISSN:
-
1420-3049
Item Description
- Language:
-
English
- Keywords:
- Pubs id:
-
1261750
- Local pid:
-
pubs:1261750
- Deposit date:
-
2022-06-22
Terms of use
- Copyright date:
- 2022
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record