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In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up.

Abstract:

To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with follow-up of 28 days or longer that were conducted between 1990 and 2003 were analyzed. These trials enrolled 13,772 patients, and participating patients comprised 23% of all patients enrolled in RCTs over the past 40 years; 61 (64%) trial arms were conducted in areas where the rate of malaria transmission was low...

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Publication status:
Published

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Authors


Stepniewska, K More by this author
Taylor, WR More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Smithuis, F More by this author
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Journal:
Antimicrobial agents and chemotherapy
Volume:
48
Issue:
11
Pages:
4271-4280
Publication date:
2004-11-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:a38f15e9-d188-4684-b79c-1f9eea646ba8
Source identifiers:
11757
Local pid:
pubs:11757

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