Journal article
The role of furin and its therapeutic potential in cardiovascular disease risk
- Abstract:
- Furin is an important proteolytic enzyme, converting several proteins from inactive precursors to their active forms. Recently, proteo-genomic analyses in European and East Asian populations suggested a causal association of furin with ischaemic heart disease, and there is growing interest in its role in cardiovascular disease (CVD) aetiology. In this narrative review, we present a critical appraisal of evidence from population studies to assess furin’s role in CVD risk and potential as a drug target for CVD. Whilst most observational studies report positive associations between furin expression and CVD risk, some studies report opposing effects, which may reflect the complex biological roles of furin and its substrates. Genetic variation in FURIN is also associated with CVD and its risk factors. We found no evidence of current clinical development of furin as a drug target for CVD, although several phase 1 and 2 clinical trials of furin inhibitors as a type of cancer immunotherapy have been completed. The growing field of proteo-genomics in large-scale population studies may inform the future development of furin and other potential drug targets to improve the treatment and prevention of CVD.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.4MB, Terms of use)
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- Publisher copy:
- 10.3390/ijms25179237
Authors
+ Wellcome Trust
More from this funder
- Funder identifier:
- https://ror.org/029chgv08
- Grant:
- 104085/Z/14/Z
- 088158/Z/09/Z
- 202922/Z/16/Z
- 212946/Z/18/Z
- Publisher:
- MDPI
- Journal:
- International Journal of Molecular Sciences More from this journal
- Volume:
- 25
- Issue:
- 17
- Article number:
- 9237
- Publication date:
- 2024-08-26
- Acceptance date:
- 2024-08-08
- DOI:
- EISSN:
-
1422-0067
- ISSN:
-
1661-6596
- Language:
-
English
- Keywords:
- Pubs id:
-
2025248
- Local pid:
-
pubs:2025248
- Deposit date:
-
2024-09-16
Terms of use
- Copyright holder:
- Fry et al
- Copyright date:
- 2024
- Rights statement:
- © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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