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Relationship between bacterial strain type, host biomarkers, and mortality in Clostridium difficile infection.

Abstract:

Background. Despite substantial interest in biomarkers, their impact on clinical outcomes and variation with bacterial strain has rarely been explored using integrated databases.

Methods. From September 2006 to May 2011, strains isolated from Clostridium difficile toxin enzyme immunoassay (EIA)–positive fecal samples from Oxfordshire, United Kingdom (approximately 600 000 people) underwent multilocus sequence typing. Fourteen-day mortality ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/cid/cit127

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Medicine, Nuffield Department of
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Medicine, Nuffield Department of
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Medicine, Nuffield Department of
Role:
Author
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National Institute for Health Research More from this funder
Medical Research Council More from this funder
Biotechnology and Biological Sciences Research Council More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Journal website
Volume:
56
Issue:
11
Pages:
1589-1600
Publication date:
2013-06-05
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
URN:
uuid:a36ae4ab-e668-4c66-9dbc-fe056b7ea967
Source identifiers:
387779
Local pid:
pubs:387779

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