Journal article
Target engagement: shining a light
- Abstract:
- The ability to measure the binding of a compound to its intended target in live cells or tissue is a critical parameter for drug discovery. A new method using polarized light microscopy adds to the current toolbox by enabling monitoring of target engagement in vitro and in vivo at single-cell resolution.
- Publication status:
- Published
- Peer review status:
- Reviewed (other)
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Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 720.6KB, Terms of use)
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- Publisher copy:
- 10.1038/nchembio.2295
Authors
- Publisher:
- Springer Nature
- Journal:
- Nature Chemical Biology More from this journal
- Volume:
- 13
- Issue:
- 2
- Pages:
- 133-134
- Publication date:
- 2017-01-19
- DOI:
- EISSN:
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1552-4469
- ISSN:
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1552-4450
- Language:
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English
- Keywords:
- Pubs id:
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pubs:672212
- UUID:
-
uuid:a32c81e6-5cd5-4f86-96a4-c5401260a259
- Local pid:
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pubs:672212
- Source identifiers:
-
672212
- Deposit date:
-
2017-01-20
- ARK identifier:
Terms of use
- Copyright holder:
- Kilian V M Huber
- Copyright date:
- 2017
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Springer Nature at: https://doi.org/10.1038/nchembio.2295
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