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Journal article

Target engagement: shining a light

Abstract:
The ability to measure the binding of a compound to its intended target in live cells or tissue is a critical parameter for drug discovery. A new method using polarized light microscopy adds to the current toolbox by enabling monitoring of target engagement in vitro and in vivo at single-cell resolution.
Publication status:
Published
Peer review status:
Reviewed (other)
Version:
Accepted Manuscript

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Publisher copy:
10.1038/nchembio.2295

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Department:
Oxford, MSD, NDM, Target Discovery Institute
Publisher:
Springer Nature Publisher's website
Journal:
Nature Chemical Biology Journal website
Volume:
13
Issue:
2
Pages:
133-134
Publication date:
2017-01-19
DOI:
EISSN:
1552-4469
ISSN:
1552-4450
Pubs id:
pubs:672212
URN:
uri:a32c81e6-5cd5-4f86-96a4-c5401260a259
UUID:
uuid:a32c81e6-5cd5-4f86-96a4-c5401260a259
Local pid:
pubs:672212

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