- Abstract:
-
The endogenous metabolite itaconate has recently emerged as a regulator of macrophage function, but its precise mechanism of action remains poorly understood1,2,3. Here we show that itaconate is required for the activation of the anti-inflammatory transcription factor Nrf2 (also known as NFE2L2) by lipopolysaccharide in mouse and human macrophages. We find that itaconate directly modifies proteins via alkylation of cysteine residues. Itaconate alkylates cysteine residues 151, 257, 288, 273 an...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 195.5KB)
-
(pdf, 6.2MB)
-
- Publisher copy:
- 10.1038/nature25986
-
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- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Journal website
- Volume:
- 556
- Issue:
- 7699
- Pages:
- 113-117
- Publication date:
- 2018-03-28
- Acceptance date:
- 2018-02-09
- DOI:
- EISSN:
-
1476-4687
- ISSN:
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0028-0836
- Pubs id:
-
pubs:833972
- URN:
-
uri:a328d53b-ce28-4ce4-aefb-839754ab5322
- UUID:
-
uuid:a328d53b-ce28-4ce4-aefb-839754ab5322
- Local pid:
- pubs:833972
- Language:
- English
- Copyright holder:
- Mills et al.
- Copyright date:
- 2018
- Notes:
-
This is the accepted manuscript version of the article. The final version is available online from Springer Nature at: https://doi.org/10.1038/nature25986
Journal article
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
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