Journal article
Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with disease severity in COVID-19
- Abstract:
- A major unanswered question in the current global COVID-19 outbreak is why a small minority of infected individuals develop severe disease. Here we report that homozygosity for the C allele of rs12252 in the interferon-induced transmembrane protein 3 (IFITM3) gene is associated with more severe disease in an age dependent manner. This supports a role for IFITM3 in disease pathogenesis and the opportunity for early targeted intervention in at risk individuals.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 190.8KB, Terms of use)
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- Publisher copy:
- 10.1093/infdis/jiaa224
Authors
- Publisher:
- Oxford University Press
- Journal:
- Journal of Infectious Diseases More from this journal
- Volume:
- 222
- Issue:
- 1
- Pages:
- 34-37
- Publication date:
- 2020-04-29
- Acceptance date:
- 2020-04-15
- DOI:
- EISSN:
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1537-6613
- ISSN:
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0022-1899
- Language:
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English
- Keywords:
- Pubs id:
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1102551
- Local pid:
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pubs:1102551
- Deposit date:
-
2020-05-01
- ARK identifier:
Terms of use
- Copyright holder:
- Zhang et al.
- Copyright date:
- 2020
- Rights statement:
- © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons AttributionNonCommercial-NoDerivs licence
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