Journal article

THE DERMO-EPIDERMAL INTERFACE IN LICHEN-PLANUS END LUPUS-ERYTHEMATOSUS

Abstract:: The pathogenesis of lichen planus (LP) and cutaneous lupus erythematosus (LE) was investigated by immunohistochemical staining of skin biopsies from eight patients with these conditions compared with controls. Monoclonal antibodies were directed against antigens of the various components of the basement membrane zone. We found a differential, site specific response by these components to the inflammatory process. The structural collagens in the basal lamina underwent a primarily reparative response demonstrated by thickening and reduplicatian, whilst an epidermal, hemidesmosome-associated antigen was consistently disrupted and fragmented. Despite diverse clinical features there were similarities between these two diseases suggesting some common pathogenic mechanisms.

Publication status:: Published

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Cite

Cite this record

APA Style

Marren, P., Deberker, D., Wojnarowska, F., Davies, M., Leigh, I., & Burge, S. (1994). THE DERMO-EPIDERMAL INTERFACE IN LICHEN-PLANUS END LUPUS-ERYTHEMATOSUS. EUROPEAN JOURNAL OF DERMATOLOGY, 4(1), 58–62.

MLA Style

Marren, P., et al. “THE DERMO-EPIDERMAL INTERFACE IN LICHEN-PLANUS END LUPUS-ERYTHEMATOSUS.” EUROPEAN JOURNAL OF DERMATOLOGY, vol. 4, no. 1, 1994, pp. 58–62.

Chicago Style

Marren, P, D Deberker, F Wojnarowska, M Davies, I Leigh, and S Burge. 1994. “THE DERMO-EPIDERMAL INTERFACE IN LICHEN-PLANUS END LUPUS-ERYTHEMATOSUS.” EUROPEAN JOURNAL OF DERMATOLOGY 4 (1): 58–62.
Share
Print

Authors

+ Marren, P More by this author

Role:: Author

+ Deberker, D More by this author

Role:: Author

+ Wojnarowska, F More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDM
Sub department:: NDM Experimental Medicine
Role:: Author

+ Davies, M More by this author

Role:: Author

+ Leigh, I More by this author

Role:: Author

More authors...

Journal:: EUROPEAN JOURNAL OF DERMATOLOGY More from this journal
Volume:: 4
Issue:: 1
Pages:: 58-62
Publication date:: 1994-01-01
ISSN:: 1167-1122

Keywords:: BASEMENT MEMBRANE ZONE

IMMUNOHISTOCHEMISTRY

LICHEN PLANUS

LUPUS ERYTHEMATOSUS

DERMO-EPIDERMAL JUNCTION
Pubs id:: pubs:5624
UUID:: uuid:a30703c2-e622-49fb-a09c-5960cb4ba0f9
Local pid:: pubs:5624
Source identifiers:: 5624
Deposit date:: 2012-12-19

Terms of use

Copyright date:: 1994

Licence:: Terms and Conditions of Use for Oxford University Research Archive

Views and Downloads

About views and downloads

If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP